刘明耀（教授）的个人简介
刘明耀男，教授，博导，1962年生于湖南，华东师范大学生命科学学院 院长，上海市调控生物学重点实验室主任，生命医学研究所所长。
人物简历
刘明耀教授，男，1962年生于湖南，1982年获湖南师范大学学士学位，1985年获湖南师范大学硕士学位，1992年获美国马里兰大学细胞生物学博士学位；1993年到1998年先后在美国约翰-霍普金斯大学医学院神经科学系和加州理工学院生物学部做博士后研究；1999至2007年先后在美国德克萨斯农工大学生物科学与技术研究所任助理教授、副教授及终身教授。
2007年受聘回国加入华东师范大学，组建生命医学研究所并任所长；2011年12月起担任上海市调控生物学重点实验室主任，同年起担任教育部创新团队带头人、国家重大科学研究计划（973项目）首席科学家；2012年入选上海市优秀学科带头人，2012年起任华东师范大学生命科学学院院长。
刘明耀教授致力于G蛋白偶联受体（GPCR）在个体发育和肿瘤及重大疾病发生发展过程中的功能及信号转导机理研究，以及靶向GPCR的新药研发。回国后作为首席科学家主持中国重大科学研究计划1项，主持国家自然科学基金重点项目2项，参与国家重大专项新药创制项目1项。已在Science、Nature、Nature Biotechnology、PNAS、J Natl Cancer Inst等国际学术刊物上发表SCI论文150多篇，申请专利30多项，获得授权专利6项。
科研项目
主持多项美国国立卫生研究院（NIH）研究项目
主持多项美国国防部（DOD）研究项目
主持中国科委973前期项目一项
主持上海市科委"细胞信号转导网络研究技术"研发公共服务平台。
科研方向
G-蛋白偶联受体及其信号转导途径基因敲除和转基因动物
细胞信号网络与疾病
血管新生与分子药理学
干细胞和发育生物学
生殖和代谢疾病
肿瘤生长与转移的分子机理
刘明耀教授的研究领域主要涉及发育和疾病过程中G-蛋白偶联受体(GPCRs)及其信号转导途径在胚胎发育和疾病发生过程中的作用（包括生殖系统、癌症、糖尿病、骨骼和心血管系统）。G-蛋白偶联受体是已知数目最多的细胞表面受体家族，它们把多种多样的胞外信号传递到细胞内，并通过和其它信号转导途径间的相互作用广泛参与细胞增殖、分化、迁移，尤其是各类生理活动和疾病的调控。刘明耀教授实验室研究的总体目标就是利用基因敲除和转基因动物技术平台研究构建疾病模型并研究GPCRs在生物体中的功能；利用细胞信号转导网络技术平台来阐明GPCRs在正常和疾病状态下的细胞和分子机制。其最终目标是开发特异靶向性膜受体和信号途径的疾病治疗药物。研究领域集中在G蛋白偶联受体(GPCRs)及其信号转导途径，包括1）发育和代谢疾病；2）肿瘤发生，发展和转移的分子机理；3）血管新生和抗血管新生药物的分子机制及新药研发；4）炎症和肿瘤免疫中G蛋白偶联受体介导的NF-КB信号途径；5）干细胞分化调控和人类疾病转基因动物模型的建立。
主要论文
1) Liu, M., Chen, T.-Y., Ahamed, B., Li, J. and Yau, K.-Y. (1994) Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel. Science 266, 1348-1354. (Research Article)
2) Liu, M. and Simon, M.I. (1996) Regulation by cAMP-dependent protein kinase of a G-protein mediated phospholipase C. Nature 38, 82-87 (1996).
3) Xia, C., Bao, Z., Tabassum, F., Qiu, M., Hua, S.-B., and Liu, M. (2000) GCIP, a novel human Grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. J. Biol. Chem. 275, 20942-20948.
4) Yue, C., Ku, CY, Liu, M., Simon, M.I., and Sanborn, B.M. (2000) Molecular mechanism of the inhibition of phospholipase C-b3 by protein kinase C. J. Biol. Chem. 275, 30220-30225.
5) Ma, W., Xia, C., Ling, P., Qiu, M., Tan, T.-H., and Liu, M. (2001) Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate the JNK signaling pathway in T cells. Oncogene 20, 1703-1714.
6) Xia, C., Bao, Z., Yu, C., Sanborn, B., and Liu, M. (2001) Regulation of G-protein mediated phospholipase C-b by cGMP-dependent protein kinase. J. Biol. Chem. 276, 19770-19777.
7) Kim, H.W., Yang, P., Qyang, Y., Lai, H., Du, H., Henkel, J.S., Kumar, K., Bao, S., Liu, M., and Marcus, S. (2001) Genetic and molecular characterization of Skb15, a highly conserved inhibitor of the fission yeast PAK, ShK1. Molecular Cell, 7, 1095-1101.
8) Xia, C., Ma, W., Stafford, L.J., Marcus, S., Xiong, W-C., and Liu, M. (2001) Regulation of the p21-activated kinase (PAK) by a novel human Gb-like WD-repeat protein, hPIP1. Proc. Natl. Acad. Sci. U.S.A. 98: 6174-6179.
9) Xia, C. Ma, W., Wang, F., Hua, S-B., and Liu, M. (2001) Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Oncogene 20, 5903-5907.
10) Luo, Z.J., Wang, Q., Zhou, J.Z., Wang, J.B., Liu, M., He, X., Wynshaw-Boris, A., Xiong, C.X., Lu, B., Mei, L. (2002) Dishevelled Mediates AChR Clustering by Interacting with MuSK and PAK1. Neuron 35, 489-505.
11) Stafford, L.J., Xia, C., Ma, W., Cai, Y., and Liu, M. (2002) Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein coupled receptor. Cancer Res. 62: 5399-5404.
12) Mukhopadhyay, A., Banerjee, S., Stafford, L.J., Xia, C., Liu, M., and Aggarwal, B.B. (2002) Curcumin-induced suppression of cell proliferation correlates with downregulation of the cyclin D1 expression and Cdk4-mediated retinoblastoma protein phosphorylation. Oncogene 21, 8852-8861.
13) Xiang, H., Wang, J., Mao, Y., Liu, M., Reddy, V., and Li, D.W. (2002) Human telomerase accelerates cell growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway. Oncogene 21, 3784-3791
14) Gu, J., Xia, C., Lu, W., Wu, X., and Liu, M. (2003) Regulation and phosphorylation of hematopoietic Ga15 and Ga16 by protein kinase C. J. Biol. Chem. 88, 1101-1111.
15) Guo, X., Stafford, L.J., Bryan, B., Xia, C., Ma, W., Wu, X., Liu, D., Songyang, Z., and Liu, M. (2003) A Rac/Cdc42 specific exchange factor, GEFT, mediates cell migration, proliferation and transformation. J. Biol. Chem. 278, 13207-13215.
16) Xia, C., Stafford, L.J., Ma, W., Cai, Y., Gong, L., Liu, C., Martin, J.F., and Liu, M. (2003) GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Mol. Cell. Biol. 23 (7), 2476-2488.
17) Li, Z., Hannigan, M., Mo, Z., Liu, B., Lu, W., Smrcka, A., Wu, G., Liu, M., Huang, C.K., and Wu, D. (2003) A novel chemoattractant-activated Gbg and PIXa-mediated signaling mechanism for activation of Cdc42 and PAK1 that is required for direction sensing and stabilization of cell polarity. Cell 114, 215-227.
18) Weng, J., Wang, J. Cai, Y., Stafford, L.J., Mitchell, D., Ittman, M., and Liu, M. (2004) Increased expression of prostate-specific G-protein coupled receptor (PSGR) in human prostate intraepithelial neoplasia (PIN) and prostate cancers. International Journal of Cancer 113 (5):811-8.
19) Bryan, B., Kumar, V., Cai, Y., Ma, W., Wu, G., and Liu, M. (2004) GEFT, a Rho-family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation. J. Biol. Chem. 279, 45824-32. Epub 2004 Aug 17.
2005年发表的论文
20) Cai, Y., Stafford, L.J., Bryan B.A., Mitchell, D. and Liu, M. (2005) G-protein activated phospholipase C, new partners for cell polarity protein Par3 and Par6. Oncogene 24: 4293-300.
21) Bryan, B., Cai, Y., Wrighton, K., Wu, G., Feng, X.H., and Liu, M. (2005) Ubiquitination of RhoA by Smurf1 Promotes Neurite Outgrowth. FEBS Letters 579: 1015-9.
22) Provost, J.J., Olmschenk S.M., Metcalf A.L., Korpi N., Thronson H., Liu M., Wallert M.A. (2005) Phospholipase C-beta1 mediates alpha1-adrenergic receptor-stimulated activation of the sodium-hydrogen exchanger in Chinese hamster lung fibroblasts (CCL39). Biochem. Cell. Biol. 83: 123-132.
23) Bryan, B.A., Li, D., Wu, X., and Liu, M. (2005) The Rho family of small GTPases: crucial regulators of skeletal myogenesis. Cell Mol. Life Sci. 62:1547-55.
24) Bryan, B.A. and Liu, M. (2005) GEFT, an exchange factor for Rho GTPases. AfCS-Nature Molecule Pages, doi:10.1038/mp.a003469.01
25) Weng, G., Ma, W., Mitchell, D., and Liu, M. (2005) Transcriptional regulation of human prostate-specific G-protein coupled receptor (PSGR) by two distinct promoters and growth factors. J. Cell. Biochem. 96:1034-1048.
26) Bryan, B.A., Mitchell, M.C., Zhao, L., Ma, W., Stafford, L.J., Teng, B.B., and Liu, M. (2005) Modulation of muscle regeneration, myogenesis and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. Mol. Cell. Biol. 25:11089-11101.
2006年发表的论文
27) Weng J, Wang J, Hu X, Wang F, Ittmann M, Liu M. (2006) PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. Int. J. Cancer 118: 1471-1480 [Epub 2005 Oct 4].
28) Mitchell, D. C., Abdelrahim, M., Weng, J., Stafford, L.J., Safe, S., Bar-Eli, M., and Liu, M. (2006) Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer. J. Biol. Chem. 281(1):51-8 [Epub 2005 Oct 27].
29) Cai, Y., Wu, P., Ozen, M., Yu, Y., Wang, J., Ittmann, M., and Liu, M. (2006) Gene expression profiling and analysis of signaling pathways of human neural stem cell priming and differentiation. Neuroscience 138(1):133-48 [Epub 2006 Jan 18].
30) Bryan, B.A., Cai, Y., and Liu, M. (2006) Rho family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth. J. Neuroscience Res. 83 (7):1151-9.
31) Wang, J., Weng, J., Cai, Y., Penland, R., Liu, M., and Ittmann, M. (2006) The prostate specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to b-methylacyl-CoA racemase. The Prostate 66 (8):847-57.
32) Ma, W., Xia, X., Stafford, L.J., Yu, C., Wang, F., LeSage, G., and Liu, M. (2006) Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. Oncogene 25, 4207-16 [Epub 2006 Feb 27].
2007年发表的论文
33) Hsu, Y-C., Chern, J.J., Cai, Y., Liu, M., and Choi, K.W. (2007) Drosophila Homolog of TCTP Regulates Cell Growth and Proliferation through regulation of dRheb GTPase. Nature 445 (7129), 785-788.
34) Li, D., Mitchell, D.C., Luo, J., Yi, Z., Cho, S.-G., Li, X., Ning, G., Wu, X., and Liu, M. (2007) Estrogen regulates KiSS1 gene expression through estrogen receptor a and SP protein complexes. Endocrinology 2007 Jul 26; [Epub ahead of print] PMID: 17656465
35) Mitchell, D.C., Bryan, B.A., Liu, J.P., Liu, W.B., Zhou, X., Qu, J., Hurwitz, R., Liu, M., and Li, D.W. (2007) Differential Expression of Rho family of GTPases during mouse eye development. Molecular Vision 13:1144-53.
36) Kunnumakkara, A.B., Nair, A.S., Ahn, K.S., Pandey, M.K., Yi, Z.F., Liu, M., and Aggarwal, B.B. (2007) Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1 mediated NF-kB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood 109 (12):5112-21. Epub 2007 Mar 1
37) Shi, H.Y., Stafford, L.J., Liu, Z., Liu, M., and Zhang, M. (2007) Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not RhoA GTPase. Cell Motility and Cytoskeleton 64 (5):338-46. [Epub 2007 Feb 14].
38) Wrighton, K.H., Liang, M., Bryan, B.A., Luo, K., Liu, M., Feng, X.H., and Lin, X. (2007) TGF-beta-independent regulation of myogenesis by SnoN sumoylation. J. Biol. Chem. 282(9):6517-24. [Epub ahead of print] PMID: 17202138
39) Ma, W., Stafford, J.L., Li, D., Luo, J., Li, X., Ning, G., and Liu, M. (2007) GCIP/ CCNDBP1, a helix-loop-helix leucine-zip protein, suppresses tumorigenesis. Journal of Cell. Biochem 100 (6):1376-86.
40) Mitchell, D.C., Stafford, L.J., Li, D., Bar-Eli, M., and Liu, M. (2007) Transcriptional Regulation of KiSS-1 Gene Expression in Metastatic Melanoma by Specificity Protein-1 and its Coactivator DRIP-130. Oncogene 26 (12):1739-47.
荣誉
- Outstanding Graduate Student Research Award, University of Maryland, 1992
- National Institutes of Health (NIH) Fellowship, 1992
- HHMI Postdoctoral Fellowship, 1993-1994
- Scientist Development Award, American Heart Association National, 1999
- Basil Ou2019Connor Scholar Award from March of Dimes Foundation, 2001
- President, Society of Chinese Bioscientists in America, Texas Chapter, 2003-2004
代表性的论文(选自60多篇SCI 文章)
